Chong Li and colleagues from the University of Minnesota provide new insights for the potential use of the heterologous prime-boost vaccination strategy to control swine infuenza A virus (IAV) infection in pigs by bringing us a research article published in Veterinary Research.
- Heterologous prime-boost vaccination has the potential to deal with diverse IAV infection in multiple animal models.
- Pigs in the heterologous prime-boost vaccination group had more favorable outcomes consistent with a better response against virus challenge (H1N1 and H3N2 IAV) than non-vaccinated pigs.
- Similarly, a multivalent heterologous inactivated vaccine boost to pigs following a single live attenuated IAV vaccine (LAIV) administration was also beneficial.
- More studies are still needed to validate the concept of heterologous prime-boost to control IAV under feld conditions.