In a new study by Paploski et al., researchers from the VanderWaal lab delineated the phylogenetic structure within PRRSV Lineage 1, described past dynamics of different viral strains through quantifying viral population sizes across time, and identified antigenically relevant amino acid changes associated with each sub-lineage.
Key points
- Lineage 1 of PRRSV-type 2, which is the most prevalent PRRSV lineage in the U.S., can be sub-divided into eight sub-lineages
- We documented the cyclic emergence and turnover of different lineages and sub-lineages (about every 3 years) in the commercial pig population based on both sequence count data and estimated past viral population sizes inferred from genetic diversity through time.
- The eight sub-lineages differed in key amino acid sites of the GP5 that are thought to be involved in the immune response to the virus. This lends further strength to the hypothesis that immune-mediated competition or selection may drive the emergence of new PRRSV sub-lineages in the U.S.
Continue reading “Phylogenetic Structure and Sequential Dominance of Sub-Lineages of PRRSV Type-2 Lineage 1 in the United States”
