Can 2 strains of PRRSv be highly homologous but have distinct virulence?

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

Key points

  • Two novel HP-PRRSV variants (XJ17-5 and JSTZ1712-12) that have the new genetic feature of 150-amino-acid deletion in nsp2 were identified.
  • Even though XJ17-5 and JSTZ1712-12 isolates share high genomic homology, they had distinct pathogenicity for piglets.
  • Fragment comparisons identified 34 amino acid differences between the two isolates which might be related to distinct virulence.
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PRRSV 1-7-4 ORF5 diversity over time

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

This week, the MSHMP team is looking at 16 years of genetic diversity of ORF-5 from the PRRS virus sequences submitted by the MSHMP participants

Key Points

  • PRRSV ORF5 sequence monitoring over time contributes to the understanding of pathogen evolution.  
  • Range of PRRSV 1-7-4 percent divergence has decreased over the last 16 years between 2003 and 2019, which is consistent with lineage turnover previously described.
  • PRRSV 1-7-4 can belong to a specific lineage or sublineage, 1A being the most common currently.
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Role of stress on early pathogenesis of Senecavirus A in pigs

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

This week, Dr. Guilherme Preis, phD candidate with Dr. Fabio Vannucci shares results of his latest research on stress and its influence on Senecavirus A.

Key points

  • Impact of a stress model on the early pathogenesis of Senecavirus A was evaluated.
  • Time to detect replicating virus in snout skins and coronary bands was 48 hours post inoculation.
  • Naïve animals likely do not have enough time to develop vesicles during most transportation events, if exposed via the nasal route.
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Shedding light on the epidemiology of Senecavirus A

PhD-candidate Guilherme Milanez Preis, working with Drs. Cesar Corzo and Fabio Vannucci on the epidemiology of Senecavirus A. In an article for the National Hog Farmer, Preis shares the latest results of his work on Senecavirus A prevalence in the USA.

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Effect of litter aggregation and pooling on detection of PRRSv in piglet processing fluids

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

The Science Page this week was written by the MSHMP team and covers pooling of processing fluids. A more detailed report can be found on the blog. Currently, a study to evaluate the number of negative processing fluids to declare a farm stable is ongoing. If you are interested in participating in this study, contact Dr. Juan Sanhueza (jsanhuez-at-umn-dot-edu).

Continue reading “Effect of litter aggregation and pooling on detection of PRRSv in piglet processing fluids”