Antimicrobial use, PRRS, and the microbiome with McKnight Land-Grant Professor Noelle Noyes

Dr. Noelle Noyes received the 2022 McKnight Land-Grant Professorship for her work on Microbes for Sustainable Intensification of Livestock Production. As the human population expands, so does its demand for protein. Livestock farmers must meet this demand, but their land and water are shrinking rapidly, meaning they must produce more with less. Dr. Noyes confronts this challenge through scientific discovery of the livestock microbiome.

Noyes receives 2022 McKnight Land-Grant Professorship

In one of their latest studies in collaboration with Pipestone Systems and Dr. Peter Davies, the Noyes lab evaluates the impact of antimicrobial use on resistance patterns in PRRS-infected pigs. The publication is available in open access in the Applied and Environmental Microbiology journal.

Despite a recognized need for more longitudinal studies to assess the effects of antimicrobial use on resistance in food animals, they remain sparse in the literature, and most longitudinal studies of pigs have been observational. The current experimental study had the advantages of greater control of potential confounding, precise measurement of antimicrobial exposures which differed markedly between groups and tracking of pigs until market age. Overall, resistance patterns were remarkably stable between the treatment groups over time, and the differences observed could not be readily reconciled with the antimicrobial exposures, indicating the likely importance of other determinants of antimicrobial resistance at the population level.

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Antimicrobial use in wean to market pigs in the United States assessed via voluntary sharing

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

This wee, Drs. Peter Davies and Randall Singer from the University of Minnesota, share a summary of their publication on the use of antimicrobials in wean-to-market pigs in the United States.

Key Points

  • Obtained data on antimicrobial use in the US swine industry through voluntary and confidential sharing of proprietary data
  • First substantial description of antimicrobial use in US swine beyond FDA sales and distribution data¬†¬†
  • Critically important classes were only 5% of use, and fluoroquinolones and ceftiofur (drugs of most concern) were <1%
  • The project is ongoing and seeking further participation from interested systems for 2018 to 2020.
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Antimicrobial use in wean to market pigs in the United States

Today, we are sharing a publication from Drs. Davies and Singer regarding antimicrobial use in wean-to-market pigs in the United States based on self-reported data from swine producers and veterinarians. This work is published in Zoonoses and Public Health in open access.

Impacts

  • Demonstrates the feasibility of obtaining data on antimicrobial use in the United States swine industry through sharing of proprietary records within industry.
  • Provides the first substantial description of antimicrobial use in United States swine beyond annual sales and distribution data.
  • Indicates that specific metrics of antibiotic use that focus on conditions within individual industries will be most useful to advance stewardship.
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