Antimicrobial use, PRRS, and the microbiome with McKnight Land-Grant Professor Noelle Noyes

Dr. Noelle Noyes received the 2022 McKnight Land-Grant Professorship for her work on Microbes for Sustainable Intensification of Livestock Production. As the human population expands, so does its demand for protein. Livestock farmers must meet this demand, but their land and water are shrinking rapidly, meaning they must produce more with less. Dr. Noyes confronts this challenge through scientific discovery of the livestock microbiome.

Noyes receives 2022 McKnight Land-Grant Professorship

In one of their latest studies in collaboration with Pipestone Systems and Dr. Peter Davies, the Noyes lab evaluates the impact of antimicrobial use on resistance patterns in PRRS-infected pigs. The publication is available in open access in the Applied and Environmental Microbiology journal.

Despite a recognized need for more longitudinal studies to assess the effects of antimicrobial use on resistance in food animals, they remain sparse in the literature, and most longitudinal studies of pigs have been observational. The current experimental study had the advantages of greater control of potential confounding, precise measurement of antimicrobial exposures which differed markedly between groups and tracking of pigs until market age. Overall, resistance patterns were remarkably stable between the treatment groups over time, and the differences observed could not be readily reconciled with the antimicrobial exposures, indicating the likely importance of other determinants of antimicrobial resistance at the population level.

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Dr. Ilya Slizovskiy receives new USDA-FSIS fellowship

Dr. Ilya Slizovskiy, PhD student in the Noyes lab, is the first recipient of a new fellowship created by the Food Safety Inspection Service, FSIS.  This competitive fellowship is committed to data-driven and science-based approaches applied to all aspects of FSIS public health mission. Slizovskiy’s project focuses on new techniques to detect antimicrobial resistances and foodborne pathogens.

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Antimicrobial resistance in swine respiratory bacterial pathogens in the USA

On this Monday morning, we would like to share with you this article published in Research in Veterinary Science by PhD-candidate Shivdeep Hayer advised by Dr. Julio Alvarez. The peer-reviewed publication is a summary of antimicrobial resistances (AMR) in swine respiratory isolates between 2006 and 2016.

Highlights

  • AMR data for bacterial swine pathogens associated with Swine Respiratory Disease Complex are lacking
  • AMR data on swine bacterial pathogens collected over 11 years in the U.S.A was analyzed for changes in AMR prevalence
  • AMR in S. suis and P. multocida isolates mostly remained low
  • There were statistically significant changes in AMR in A. suis and H. parasuis
  • Use of surrogate breakpoints can lead to different AMR estimates for certain bacteria
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Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets

It is the end of the year and to celebrate, here is one of the favorite Science Pages of the year, from Dr. Lowe’s team at the University of Illinois.

Keypoints

  • Early life antimicrobial prophylaxis had no effect on individual weight gain, or mortality but it was associated with minor shifts in the composition of fecal microbiota and noticeable changes in the abundance of selected Antimicrobial Resistant Genes
  • The shifts in fecal microbiota structure caused by perinatal antimicrobial intervention are modest and limited to particular groups of microbial taxa
  • Early life PPG and TUL intervention could promote the selection of Anrimicrobial Resistant Genes in herds
Continue reading “Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets”

Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets

This week’s Science Page presents the results of a project done by Zeineldin et al. from Dr. Jim Lowe’s program at the University of Illinois.

Keypoints

  • Early life antimicrobial prophylaxis had no effect on individual weight gain, or mortality but it was associated with minor shifts in the composition of fecal microbiota and noticeable changes in the abundance of selected Antimicrobial Resistant Genes
  • The shifts in fecal microbiota structure caused by perinatal antimicrobial intervention are modest and limited to particular groups of microbial taxa
  • Early life PPG and TUL intervention could promote the selection of Anrimicrobial Resistant Genes in herds
Continue reading “Effect of Single Dose of Antimicrobial Administration at Birth on Fecal Microbiota Development and Prevalence of Antimicrobial Resistance Genes in Piglets”