In this final episode, Dr. Montserrat Torremorell (University of Minnesota), Dr. Amy Vincent (USDA Agricultural Research Service), Dr. Christa Goodell (Boehringer Ingelheim), Dr. Gordon Spronk (Pipestone Veterinary Services), and Dr. Tom Wetzell (Boehringer Ingelheim) discuss the control of IAV-S, the research & development of vaccines for IAV-S, and the products that are being developed from the research.
No single strategy will confer total protection. A well-orchestrated combination of various methods adjusted to a single production unit or system will be needed.
Indeed, Dr. Pieters reminds us that 3 different approaches can be combined to achieve greater disease control:
No single strategy will confer total protection from infection with M. hyopneumoniae or disease elimination. However, a well-orchestrated combination of various methods, not only directed at clinical signs, but to the root of disease spread and transmission, adjusted to the unique characteristics of a production unit or system, is necessary to reach the goal of controlling M. hyopneumoniae infections and improving overall swine production around the world.
Our latest collaboration with the National Hog Farmer was written by Drs. Montse Torremorell and Marie Culhane from the University of Minnesota.
Flu never seems to go away in some herds and that is because there are groups of pigs, or subpopulations, that are able to maintain and spread the flu virus.
One of the most important subpopulations that have been identified as sources of virus on a farm is the piglets. Piglets may be infected, but may not show any signs of disease, and as a result, are silent spreaders of flu. Then, at weaning, a small, but significant, percentage of the piglets can be subclinically infected with flu, meaning they appear healthy but are shedding flu at the nursery or wean-to-finish site.
This causes a challenge for producers because even though piglets are born free of flu, they tend to be contaminated by the dam during their second week of like. The peak of flu-positive piglets occurs at weaning when piglets are moved to a nursery where they may be put in contact with naive piglets from another source and therefore become a major source of infection.
We need to understand how piglets become infected in the farrowing room in order to prevent it. Sow vaccination is a tool commonly used to protect piglets via the transmission of antibodies through the colostrum or maternal immunity. It has been shown to decrease the prevalence of flu-positive piglets at weaning but is insufficient to constantly wean negative animals.
“At the University of Minnesota, we have been measuring the impact of piglets on the spread of flu for years. We found, in a study by Allerson of 52 swine breeding herds in the United States, 23 herds (44%) tested IAV RT-PCR positive at least once during a six-month study period. Groups of piglets from those herds also tested positive for flu at weaning about 25% (75 of 305) of the time.
Along those same lines, Chamba and partnering sow farms reported that out of the 34 farms studied for more than five years, all sow farms tested positive for flu at one time or another and the level of flu infection in the groups of weaned pigs ranged from 7% to 57%. More importantly, in this study, approximately 28% (427 of 1,523) of groups of pigs tested positive at weaning. […]
Ultimately, the successful control of on-going flu infections in growing pigs will depend on the sow farm’s ability to wean a negative pig […]”
Enzootic pneumoniae is a chronic respiratory disease caused by Mycoplasma hyopneumoniae in pigs. It has been present in the industry for decades and causes significant economic losses. Yet, control methods like vaccination have not been able to contain the disease. Why is that? What information are we missing to design more effective control methods? This is the goal of the review paper co-authored by Dr. Maria Pieters from the University of Minnesota.
Focusing on various aspects of the disease like epidemiology, pathogenicity, diagnostics, and control measures, this publication regroups all the knowledge we currently have of Mycoplasma hyopneumoniae and identifies what we need to investigate to improve disease control.
Click on the banner below to access the full article.
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary pathogen of enzootic pneumonia, a chronic respiratory disease in pigs. Infections occur worldwide and cause major economic losses to the pig industry. The present paper reviews the current knowledge on M. hyopneumoniae infections, with emphasis on identification and analysis of knowledge gaps for optimizing control of the disease. Close contact between infected and susceptible pigs is the main route of M. hyopneumoniae transmission. Management and housing conditions predisposing for infection or disease are known, but further research is needed to better understand M. hyopneumoniae transmission patterns in modern pig production systems, and to assess the importance of the breeding population for downstream disease control. The organism is primarily found on the mucosal surface of the trachea, bronchi and bronchioles. Different adhesins and lipoproteins are involved in the adherence process. However, a clear picture of the virulence and pathogenicity of M. hyopneumoniae is still missing. The role of glycerol metabolism, myoinositol metabolism and the Mycoplasma Ig binding protein—Mycoplasma Ig protease system should be further investigated for their contribution to virulence. The destruction of the mucociliary apparatus, together with modulating the immune response, enhances the susceptibility of infected pigs to secondary pathogens. Clinical signs and severity of lesions depend on different factors, such as management, environmental conditions and likely also M. hyopneumoniae strain. The potential impact of strain variability on disease severity is not well defined. Diagnostics could be improved by developing tests that may detect virulent strains, by improving sampling in live animals and by designing ELISAs allowing discrimination between infected and vaccinated pigs. The currently available vaccines are often cost-efficient, but the ongoing research on developing new vaccines that confer protective immunity and reduce transmission should be continued, as well as optimization of protocols to eliminate M. hyopneumoniae from pig herds.