Can 2 strains of PRRSv be highly homologous but have distinct virulence?

This is our Friday rubric: every week a new Science Page from the Bob Morrison’s Swine Health Monitoring Project. The previous editions of the science page are available on our website.

Key points

  • Two novel HP-PRRSV variants (XJ17-5 and JSTZ1712-12) that have the new genetic feature of 150-amino-acid deletion in nsp2 were identified.
  • Even though XJ17-5 and JSTZ1712-12 isolates share high genomic homology, they had distinct pathogenicity for piglets.
  • Fragment comparisons identified 34 amino acid differences between the two isolates which might be related to distinct virulence.
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